Adrian Jacques Ambrose, MD, MPH, FAPA, medical director of the Columbia Psychiatry Faculty Practice Organization, discusses the newest research into the neuroscience of anxiety and depression.
“Ketamine is a medical treatment intended to address a significant illness,” such as severe depression or suicidal ideation, said Joshua Berman, assistant professor of psychiatry at Columbia.
"Many patients report rapid improvement in mood, anxiety and hedonic function, which is what initially attracted the psychiatric profession to the use of ketamine," said Dr. Joshua Berman.
Excited delirium has no standard definition. The commonly cited characteristics include superhuman strength, imperviousness to pain and wild, uncontrollable behavior, said Dr. Paul S. Appelbaum.
Dr. Michael Grunebaum says that in his clinical trials, many patients don’t find that the drug relieves anxiety. “Ketamine is just a really distinct, weird, spacey feeling,” he says.
Dr. Elias Dakwar said he became interested in ketamine as a potential treatment for alcohol use disorder after seeing good results from using the drug to treat cocaine addiction.
Researchers findings at Columbia University Vagelos College of Physicians and Surgeons and New York State Psychiatric Institute could lead to a new approach to the treatment of alcohol use disorder.
Dr. Elias Dakwar sought proof of the suggestion that concentrated doses of ketamine may help reduce vulnerabilities associated with cocaine use, and improve the likelihood of relapse prevention.
“As we treat more people with ketamine, an unfortunate side effect of that is more exposure, which means that we're going to create more ketamine addicts,” said Dr. Drew Ramsey.
Dr. J. John Mann says while there are clear short-term benefits to ketamine, its long-term effects, its abuse potential and the optimal number of treatments a patient should receive are still unknown.