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Dr. Mark Olfson said that recognizing a younger person’s distress, talking about those feelings, and guiding him or her to professional help quickly can save a life and get a Gen Zer back on track.

“In addition to a more granular conceptualization of anhedonia, future studies would greatly benefit from assessment of anhedonic behavior in daily life,” writes Dr. Randy P. Auerbach and colleagues.

"As far as prevention goes, the beneficial effect of ramelteon looks pretty strong, but the amount of evidence for its efficacy is actually pretty low," Dr. Peter Shapiro said.

Dr. Paul S. Appelbaum and colleague examine the multiple changes looming in both the doctor’s and the patient’s roles in the move toward precision medicine.