The trial did not replicate the improvements in Mullen scores and in adaptive behavior that “led most people to be excited about the original paper,” says Dr. Jeremy Veenstra-VanderWeele.
Dr. Mark Olfson said that recognizing a younger person’s distress, talking about those feelings, and guiding him or her to professional help quickly can save a life and get a Gen Zer back on track.
“In addition to a more granular conceptualization of anhedonia, future studies would greatly benefit from assessment of anhedonic behavior in daily life,” writes Dr. Randy P. Auerbach and colleagues.
"As far as prevention goes, the beneficial effect of ramelteon looks pretty strong, but the amount of evidence for its efficacy is actually pretty low," Dr. Peter Shapiro said.
Dr. Paul S. Appelbaum and colleague examine the multiple changes looming in both the doctor’s and the patient’s roles in the move toward precision medicine.
“Going from not knowing each other to identifying shared interests is one of the first steps in making new friends and apps, online communities, the internet can fast track that,” Dr. Ali Mattu said.
“Approval of esketamine is important for patients because other options like transcranial magnetic stimulation work more poorly in medication-resistant depression,” writes Dr. J. John Mann.
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