Translational Neurobiology of Development (TrND) Research Group

Publications

For a list of all publications, refer to the National Center for Biotechnology Information

2023

  • Wang Z, Yueh H, Chau M, Veenstra-VanderWeele J, O'Reilly KC. Circuits underlying social function and dysfunction. Autism Res 16:1268-1288.
  • Veenstra-VanderWeele J, O'Reilly KC, Dennis MY, Uribe-Salazar JM, Amaral DG. Translational Neuroscience Approaches to Understanding Autism. Am J Psychiatry 180:265-276.
  • Vandana P, Veenstra-VanderWeele J. Editorial: Failing in our Responsibility to Address Obesity Caused by Psychotropic Medications. J Am Acad Child Adolesc Psychiatry.
  • Tobe R, Zhu Y, Gleissl T, Rossomanno S, Veenstra-VanderWeele J, Smith J, Hollander E. Predictors of placebo response in three large clinical trials of the V1a receptor antagonist balovaptan in autism spectrum disorder. Neuropsychopharmacology 48:1201-1216.
  • Siecinski SK, Giamberardino SN, Spanos M, Hauser AC, Gibson JR, Chandrasekhar T, Trelles MDP, Rockhill CM, Palumbo ML, Cundiff AW, Montgomery A, Siper P, Minjarez M, Nowinski LA, Marler S, Kwee LC, Shuffrey LC, Alderman C, Weissman J, Zappone B, Mullett JE, Crosson H, Hong N, Luo S, She L, Bhapkar M, Dean R, Scheer A, Johnson JL, King BH, McDougle CJ, Sanders KB, Kim SJ, Kolevzon A, Veenstra-VanderWeele J, Hauser ER, Sikich L, Gregory SG. Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder. Autism Res 16:502-523.
  • Salazar de Pablo G, Pastor Jorda C, Vaquerizo-Serrano J, Moreno C, Cabras A, Arango C, Hernandez P, Veenstra-VanderWeele J, Simonoff E, Fusar-Poli P, Santosh P, Cortese S, Parellada M. Systematic Review and Meta-analysis: Efficacy of Pharmacological Interventions for Irritability and Emotional Dysregulation in Autism Spectrum Disorder and Predictors of Response. J Am Acad Child Adolesc Psychiatry 62:151-168.
  • Olsen LC, Galler M, Witter MP, Saetrom P, O'Reilly KC. Transcriptional development of the hippocampus and the dorsal-intermediate-ventral axis in rats. Hippocampus 33:1028-1047.
  • Nygaard KR, Maloney SE, Swift RG, McCullough KB, Wagner RE, Fass SB, Garbett K, Mirnics K, Veenstra-VanderWeele J, Dougherty JD. Extensive characterization of a Williams syndrome murine model shows Gtf2ird1-mediated rescue of select sensorimotor tasks, but no effect on enhanced social behavior. Genes Brain Behav 22:e12853.
  • Montgomery A, Masi A, Whitehouse A, Veenstra-VanderWeele J, Shuffrey L, Shen MD, Karlov L, Uljarevic M, Alvares G, Woolfenden S, Silove N, Eapen V. Identification of subgroups of children in the Australian Autism Biobank using latent class analysis. Child Adolesc Psychiatry Ment Health 17:27.
  • Labouesse M, Torres-Herraez A, Chohan M, Villarin J, Greenwald J, Sun X, Zahran M, Tang A, Lam S, Veenstra-VanderWeele J, Lacefield C, Bonaventura J, Michaelides M, Chan S, Yizhar O, Kellendonk C. A non-canonical striatopallidal "Go" pathway that supports motor control. Res Sq.
  • Firestein MR, Shuffrey LC, Hu Y, Kyle M, Hussain M, Bianco C, Hott V, Hyman SP, Kyler M, Rodriguez C, Tejeda Romero M, Tzul Lopez H, Alcantara C, Amso D, Austin J, Bain JM, Barbosa J, Battarbee AN, Bruno A, Ettinger S, Factor-Litvak P, Gilboa S, Goldman S, Gyamfi-Bannerman C, Maniatis P, Marsh R, Morrill T, Mourad M, Muhle R, Newes-Adeyi G, Noble KG, O'Reilly KC, Penn AA, Reichle L, Sania A, Semenova V, Silver WG, Smotrich G, Tita AT, Tottenham N, Varner M, Welch MG, Zork N, Garey D, Fifer WP, Stockwell MS, Monk C, Dawood F, Dumitriu D. Assessment of Neurodevelopment in Infants With and Without Exposure to Asymptomatic or Mild Maternal SARS-CoV-2 Infection During Pregnancy. JAMA Netw Open 6:e237396.
  • Chohan MO, Fein H, Mirro S, O'Reilly KC, Veenstra-VanderWeele J. Repeated chemogenetic activation of dopaminergic neurons induces reversible changes in baseline and amphetamine-induced behaviors. Psychopharmacology (Berl).
  • Berry-Kravis E, Abbeduto L, Hagerman R, Coffey CS, Cudkowicz M, Erickson CA, McDuffie A, Hessl D, Ethridge LE, Tassone F, Kaufmann WE, Friedmann K, Bullard L, Hoffmann A, Veenstra-VanderWeele J, Staley K, Klements D, Moshinsky M, Harkey B, Long JD, Fedler J, Klingner E, Ecklund DJ, Costigan M, Huff T, Pearson B. Effects of AFQ056 on language learning in fragile X syndrome. J Clin Invest.
  • Abi-Dargham A, Moeller SJ, Ali F, DeLorenzo C, Domschke K, Horga G, Jutla A, Kotov R, Paulus MP, Rubio JM, Sanacora G, Veenstra-VanderWeele J, Krystal JH. Candidate biomarkers in psychiatric disorders: state of the field. World Psychiatry 22:236-262.

2022

  • Zuniga-Kennedy M, Davoren M, Shuffrey LC, Luna RA, Savidge T, Prasad V, Anderson GM, Veenstra-VanderWeele J, Williams KC. Intestinal Predictors of Whole Blood Serotonin Levels in Children With or Without Autism. J Autism Dev Disord 52:3780-3789.
  • Shuffrey LC, Firestein MR, Kyle MH, Fields A, Alcantara C, Amso D, Austin J, Bain JM, Barbosa J, Bence M, Bianco C, Fernandez CR, Goldman S, Gyamfi-Bannerman C, Hott V, Hu Y, Hussain M, Factor-Litvak P, Lucchini M, Mandel A, Marsh R, McBrian D, Mourad M, Muhle R, Noble KG, Penn AA, Rodriguez C, Sania A, Silver WG, O'Reilly KC, Stockwell M, Tottenham N, Welch MG, Zork N, Fifer WP, Monk C, Dumitriu D. Association of Birth During the COVID-19 Pandemic With Neurodevelopmental Status at 6 Months in Infants With and Without In Utero Exposure to Maternal SARS-CoV-2 Infection. JAMA Pediatr 176:e215563.
  • Jutla A, Foss-Feig J, Veenstra-VanderWeele J. Autism spectrum disorder and schizophrenia: An updated conceptual review. Autism Res 15:384-412.
  • Jutla A, Donohue MR, Veenstra-VanderWeele J, Foss-Feig JH. Reported autism diagnosis is associated with psychotic-like symptoms in the Adolescent Brain Cognitive Development cohort. Eur Child Adolesc Psychiatry 31:1-10.
  • Jacob S, Veenstra-VanderWeele J, Murphy D, McCracken J, Smith J, Sanders K, Meyenberg C, Wiese T, Deol-Bhullar G, Wandel C, Ashford E, Anagnostou E. Efficacy and safety of balovaptan for socialisation and communication difficulties in autistic adults in North America and Europe: a phase 3, randomised, placebo-controlled trial. Lancet Psychiatry 9:199-210.
  • Jacob S, Anagnostou E, Hollander E, Jou R, McNamara N, Sikich L, Tobe R, Murphy D, McCracken J, Ashford E, Chatham C, Clinch S, Smith J, Sanders K, Murtagh L, Noeldeke J, Veenstra-VanderWeele J. Large multicenter randomized trials in autism: key insights gained from the balovaptan clinical development program. Mol Autism 13:25.
  • Hollander E, Jacob S, Jou R, McNamara N, Sikich L, Tobe R, Smith J, Sanders K, Squassante L, Murtagh L, Gleissl T, Wandel C, Veenstra-VanderWeele J. Balovaptan vs Placebo for Social Communication in Childhood Autism Spectrum Disorder: A Randomized Clinical Trial. JAMA Psychiatry 79:760-769.
  • Chohan MO, Yueh H, Fein H, Kopelman JM, Ahmari SE, Veenstra-VanderWeele J. Intact amphetamine-induced behavioral sensitization in mice with increased or decreased neuronal glutamate transporter SLC1A1/EAAT3. Neurochem Int 160:105418.
  • Chohan MO, Kopelman JM, Yueh H, Fazlali Z, Greene N, Harris AZ, Balsam PD, Leonardo ED, Kramer ER, Veenstra-VanderWeele J, Ahmari SE. Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior. Mol Psychiatry 27:1515-1526.
  • Carpenter KLH, Davis NO, Spanos M, Sabatos-DeVito M, Aiello R, Baranek GT, Compton SN, Egger HL, Franz L, Kim SJ, King BH, Kolevzon A, McDougle CJ, Sanders K, Veenstra-VanderWeele J, Sikich L, Kollins SH, Dawson G. Adaptive Behavior in Young Autistic Children: Associations with Irritability and ADHD Symptoms. J Autism Dev Disord.
  • Beversdorf DQ, Anagnostou E, Hardan A, Wang P, Erickson CA, Frazier TW, Veenstra-VanderWeele J. Editorial: Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m). Front Psychiatry 13:1079006.

2021

  • Sikich L, Kolevzon A, King BH, McDougle CJ, Sanders KB, Kim SJ, Spanos M, Chandrasekhar T, Trelles MDP, Rockhill CM, Palumbo ML, Witters Cundiff A, Montgomery A, Siper P, Minjarez M, Nowinski LA, Marler S, Shuffrey LC, Alderman C, Weissman J, Zappone B, Mullett JE, Crosson H, Hong N, Siecinski SK, Giamberardino SN, Luo S, She L, Bhapkar M, Dean R, Scheer A, Johnson JL, Gregory SG, Veenstra-VanderWeele J. Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder. N Engl J Med 385:1462-1473.
  • Pasca SP, Veenstra-VanderWeele J, McPartland JC. Research and training in autism spectrum disorder to catalyze the next genomic and neuroscience revolutions. Mol Psychiatry 26:1429-1431.
  • O'Reilly KC, Connor M, Pierson J, Shuffrey LC, Blakely RD, Ahmari SE, Veenstra-VanderWeele J. Serotonin 5-HT(1B) receptor-mediated behavior and binding in mice with the overactive and dysregulated serotonin transporter Ala56 variant. Psychopharmacology (Berl) 238:1111-1120.
  • McCracken JT, Anagnostou E, Arango C, Dawson G, McPartland J, Murphy D, Pandina G, Veenstra-VanderWeele J, Group IEAW. Corrigendum to "Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions. [European Neuropsychopharmacology Volume 48, July 2021, Pages 3-31]". Eur Neuropsychopharmacol 50:133-134.
  • McCracken JT, Anagnostou E, Arango C, Dawson G, Farchione T, Mantua V, McPartland J, Murphy D, Pandina G, Veenstra-VanderWeele J, Group IEAW. Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions. Eur Neuropsychopharmacol 48:3-31.
  • Hosoda M, Veenstra-VanderWeele J, Stroeh OM. Gender Disparities in the Child Psychiatry Ranks. J Am Acad Child Adolesc Psychiatry 60:793-795.
  • Chohan MO, Esses S, Haft J, Ahmari SE, Veenstra-VanderWeele J. Correction to: Altered baseline and amphetamine-mediated behavioral profiles in dopamine transporter Cre (DAT-Ires-Cre) mice compared to tyrosine hydroxylase Cre (TH-Cre) mice. Psychopharmacology (Berl) 238:321.

2020

  • Siegel M, McGuire K, Veenstra-VanderWeele J, Stratigos K, King B, American Academy of C, Adolescent Psychiatry Committee on Quality I, Bellonci C, Hayek M, Keable H, Rockhill C, Bukstein OG, Walter HJ. Practice Parameter for the Assessment and Treatment of Psychiatric Disorders in Children and Adolescents With Intellectual Disability (Intellectual Developmental Disorder). J Am Acad Child Adolesc Psychiatry 59:468-496.
  • Siemann JK, Veenstra-VanderWeele J, Wallace MT. Approaches to Understanding Multisensory Dysfunction in Autism Spectrum Disorder. Autism Res 13:1430-1449.
  • Spanos M, Chandrasekhar T, Kim SJ, Hamer RM, King BH, McDougle CJ, Sanders KB, Gregory SG, Kolevzon A, Veenstra-VanderWeele J, Sikich L. Rationale, design, and methods of the Autism Centers of Excellence (ACE) network Study of Oxytocin in Autism to improve Reciprocal Social Behaviors (SOARS-B). Contemp Clin Trials 98:106103.
  • Tsamis KI, Lagartos Donato MJ, Dahl AG, O'Reilly KC, Witter MP. Development and topographic organization of subicular projections to lateral septum in the rat brain. Eur J Neurosci 52:3140-3159.
  • O'Reilly KC, Anacker AMJ, Rogers TD, Forsberg CG, Wang J, Zhang B, Blakely RD, Veenstra-VanderWeele J. A social encounter drives gene expression changes linked to neuronal function, brain development, and related disorders in mice expressing the serotonin transporter Ala56 variant. Neurosci Lett 730:135027.
  • McGuire K, Veenstra-VanderWeele J. Editorial: Important First Look at Population-Based Trajectories of Youths With Autism. J Am Acad Child Adolesc Psychiatry 59:1321-1323.
  • Lord C, Brugha TS, Charman T, Cusack J, Dumas G, Frazier T, Jones EJH, Jones RM, Pickles A, State MW, Taylor JL, Veenstra-VanderWeele J. Autism spectrum disorder. Nat Rev Dis Primers 6:5.
  • Jutla A, Turner JB, Green Snyder L, Chung WK, Veenstra-VanderWeele J. Psychotic symptoms in 16p11.2 copy-number variant carriers. Autism Res 13:187-198.
  • Jutla A, Califano A, Dishy G, Hesson H, Kennedy L, Lundgren B, Pia T, Veenstra-VanderWeele J, Brucato G, Girgis RR. Neurodevelopmental predictors of conversion to schizophrenia and other psychotic disorders in adolescence and young adulthood in clinical high risk individuals. Schizophr Res 224:170-172.
  • Chohan MO, Esses S, Haft J, Ahmari SE, Veenstra-VanderWeele J. Altered baseline and amphetamine-mediated behavioral profiles in dopamine transporter Cre (DAT-Ires-Cre) mice compared to tyrosine hydroxylase Cre (TH-Cre) mice. Psychopharmacology (Berl) 237:3553-3568.
  • Anagnostou E, Levy SE, Mazurek MO, Veenstra-VanderWeele J. Editors' Note and Prologue. Pediatrics 145:S1-S4.
  • Amaral DG, de Vries PJ. COVID-19 and Autism Research: Perspectives from Around the Globe. Autism Res 13:844-869.

2019

  • Underhill SM, Ingram SL, Ahmari SE, Veenstra-VanderWeele J, Amara SG. Neuronal excitatory amino acid transporter EAAT3: Emerging functions in health and disease. Neurochem Int 123:69-76.
  • Taylor BJ, Sanders KB, Kyle M, Pedersen KA, Veenstra-Vanderweele J, Siegel M. Inpatient Psychiatric Treatment of Serious Behavioral Problems in Children with Autism Spectrum Disorder (ASD): Specialized Versus General Inpatient Units. J Autism Dev Disord 49:1242-1249.
  • O'Reilly KC, Perica MI, Fenton AA. Synaptic plasticity/dysplasticity, process memory and item memory in rodent models of mental dysfunction. Schizophr Res 207:22-36.
  • Martinez A, Tobe R, Dias EC, Ardekani BA, Veenstra-VanderWeele J, Patel G, Breland M, Lieval A, Silipo G, Javitt DC. Differential Patterns of Visual Sensory Alteration Underlying Face Emotion Recognition Impairment and Motion Perception Deficits in Schizophrenia and Autism Spectrum Disorder. Biol Psychiatry 86:557-567.
  • Margolis KG, Buie TM, Turner JB, Silberman AE, Feldman JF, Murray KF, McSwiggan-Hardin M, Levy J, Bauman ML, Veenstra-VanderWeele J, Whitaker AH, Winter HS. Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder. J Autism Dev Disord 49:349-362.
  • Levy ERJ, O'Reilly KC, Fenton AA. Long-Lasting Input-Specific Experience-Dependent Changes of Hippocampus Synaptic Function Measured in the Anesthetized Rat. eNeuro 6.
  • Jutla A, Reed H, Veenstra-VanderWeele J. The Architecture of Autism Spectrum Disorder Risk: What Do We Know, and Where Do We Go From Here? JAMA Psychiatry 76:1005-1006.
  • Garfunkel D, Anagnostou EA, Aman MG, Handen BL, Sanders KB, Macklin EA, Chan J, Veenstra-VanderWeele J. Pharmacogenetics of Metformin for Medication-Induced Weight Gain in Autism Spectrum Disorder. J Child Adolesc Psychopharmacol 29:448-455.
  • Ferguson BJ, Dovgan K, Severns D, Martin S, Marler S, Gross Margolis K, Bauman ML, Veenstra-VanderWeele J, Sohl K, Beversdorf DQ. Lack of Associations Between Dietary Intake and Gastrointestinal Symptoms in Autism Spectrum Disorder. Front Psychiatry 10:528.
  • Canto CB, Koganezawa N, Lagartos-Donate MJ, O'Reilly KC, Mansvelder HD, Witter MP. Postnatal Development of Functional Projections from Parasubiculum and Presubiculum to Medial Entorhinal Cortex in the Rat. J Neurosci 39:8645-8663.
  • Anacker AMJ, Moran JT, Santarelli S, Forsberg CG, Rogers TD, Stanwood GD, Hall BJ, Delpire E, Veenstra-VanderWeele J, Saxe MD. Enhanced Social Dominance and Altered Neuronal Excitability in the Prefrontal Cortex of Male KCC2b Mutant Mice. Autism Res 12:732-743.
  • Aaron E, Montgomery A, Ren X, Guter S, Anderson G, Carneiro AMD, Jacob S, Mosconi M, Pandey GN, Cook E, Veenstra-VanderWeele J. Whole Blood Serotonin Levels and Platelet 5-HT(2A) Binding in Autism Spectrum Disorder. J Autism Dev Disord 49:2417-2425.

2018

  • Veenstra-VanderWeele J. Recognizing the Problem of Suicidality in Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry 57:302-303.
  • Sultan RS, Correll CU, Zohar J, Zalsman G, Veenstra-VanderWeele J. What's in a Name? Moving to Neuroscience-Based Nomenclature in Pediatric Psychopharmacology. J Am Acad Child Adolesc Psychiatry 57:719-721.
  • Robson MJ, Quinlan MA, Margolis KG, Gajewski-Kurdziel PA, Veenstra-VanderWeele J, Gershon MD, Watterson DM, Blakely RD. p38alpha MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proc Natl Acad Sci U S A 115:E10245-E10254.
  • O'Reilly KC, Levy ERJ, Patino AV, Perica MI, Fenton AA. Sub-circuit alterations in dorsal hippocampus structure and function after global neurodevelopmental insult. Brain Struct Funct 223:3543-3556.
  • Muhle RA, Reed HE, Stratigos KA, Veenstra-VanderWeele J. The Emerging Clinical Neuroscience of Autism Spectrum Disorder: A Review. JAMA Psychiatry 75:514-523.
  • Muhle RA, Reed HE, Aguayo P, Veenstra-VanderWeele J. Evaluation and Management of Self-injury in a Child With a Rare Genomic Variant. JAMA Psychiatry 75:524-525.
  • Montgomery AK, Shuffrey LC, Guter SJ, Anderson GM, Jacob S, Mosconi MW, Sweeney JA, Turner JB, Sutcliffe JS, Cook EH, Jr., Veenstra-VanderWeele J. Maternal Serotonin Levels Are Associated With Cognitive Ability and Core Symptoms in Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry 57:867-875.
  • Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J. Autism spectrum disorder. Lancet 392:508-520.
  • Handen BL, Veenstra-VanderWeele J, Anagnostou E, Aman MG. Dr. Handen et al. Reply. J Am Acad Child Adolesc Psychiatry 57:793-795.
  • Ellegood J, Yee Y, Kerr TM, Muller CL, Blakely RD, Henkelman RM, Veenstra-VanderWeele J, Lerch JP. Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging. Mol Autism 9:24.
  • Ameis SH, Kassee C, Corbett-Dick P, Cole L, Dadhwal S, Lai MC, Veenstra-VanderWeele J, Correll CU. Systematic review and guide to management of core and psychiatric symptoms in youth with autism. Acta Psychiatr Scand 138:379-400.
  • Aman MG, Hollway JA, Veenstra-VanderWeele J, Handen BL, Sanders KB, Chan J, Macklin E, Arnold LE, Wong T, Newsom C, Hastie Adams R, Marler S, Peleg N, Anagnostou EA. Effects of Metformin on Spatial and Verbal Memory in Children with ASD and Overweight Associated with Atypical Antipsychotic Use. J Child Adolesc Psychopharmacol 28:266-273.