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Showing women a photo of their mother, and imaging their brains, consistently showed differences between those who were depressed and those who were not.
There is no clear diagnosis for depression, and many slip under the medical radar with subtle symptoms of chronic fatigue. If doctors can find a brain imaging tool to reliably identify the disorder, many like Gruss's mother might be helped.
"Freud comes in to this," said co-author and psychiatrist Dr. Igor Galynker of Beth Israel Medical Center. "He blamed everything on the mother and it turns out the mother is absolutely the strongest gauge of depression you have."